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In TNF-transgenic mice lacking IL-1, bone damage is reduced, indicating that IL-1 is necessary for TNF--mediated bone loss, and IL-1 receptor antagonists can prevent this loss (60)

In multiple myeloma (MM), interaction with bone marrow stromal cells (BMSCs) via CD40CD40 ligand (CD40LG) signaling increases iron accumulation and activates the steroid biosynthesis pathway in MM cells, leading to enhanced lanosterol production

The FAD-enzyme monodehydroascorbate radical reductase mediates photoproduction of superoxide radicals in spinach thylakoid membranes