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Long-acting insulin combined with GLP-1 injections (once daily): Some people with type 2 diabetes use a single daily shot that includes a basal insulin and a GLP-1 medication, such as insulin glargine/lixisenatide (SOLIQUA 100/33) or insulin degludec/liraglutide (XULTOPHY 100/3.6)
Biochemical and Biophysical Research Communications Endogenous GLP-1 acts on paraventricular nucleus to suppress feeding : Projection from nucleus tractus solitarius and activation of corticotropin-releasing hormone, nesfatin-1 and oxytocin neurons
This slowed down state is what helps you maintain your weight loss over the long term by preventing the return of intense food noise and constant hunger
Each agent differs in pharmacokinetic properties, therapeutic efficacy, adverse event profiles, and modes of administration, necessitating individualized evaluation
