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A prospective proof-of-concept study by Nicolau et al 19 found that liraglutide treatment for three months resulted in a decrease in BMI (from 39.3 to 35.6 kg/m 2 ), waist circumference (from 121.3 to 110.6 cm), mean Hurley stage (from 2.6 to 1.1), DLQI (from 12.3 to 9.7), Beck Depression Inventory (BDI) (from 22 to 16.7), and visual analog scale (VAS) for pain (from 5.6 to 3.2), as well as a decrease in inflammatory markers such as CRP (from 4.5 to 3 mg/dL), homocysteine (from 16.2 to 13.3 mol/L), plasma morning cortisol (from 15.9 to 12.6 g/dL), and insulin (from 18.9 to 15.7 U/mL)

Rajsree Nambudripads in-depth video on Estrogen Dominance , which explains: How gut health and liver function impact estrogen metabolism Why dysbiosis can cause high beta-glucuronidase levels in the gut, which can lead to estrogen recycling Natural strategies to support estrogen detoxification and balance hormones The Gut Microbiomes Role in Estrogen Detoxification Regardless of genetic predisposition, optimizing estrogen metabolism is key to reducing breast cancer risk

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