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What to set as your healthy expectation if youre starting GLP-1 If you want a clean, realistic way to frame it: First 12 months: appetite shifts + early weight movement By ~4 months: more noticeable progress (if dose escalation is tolerated) (Source: European Medicines Agency (EMA)) By ~1216 months: many eligible adults land in the 1015% weight-loss range (some higher, some lower) (Source: New England Journal of Medicine) Best outcomes happen when you protect muscle (protein + strength) and build routines you can sustain.