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Instead of targeting one receptor, it activates three simultaneously: GLP-1, GIP (glucose-dependent insulinotropic polypeptide), and the glucagon receptor
GHRP-6, the first widely studied GHRP, was shown to stimulate robust GH release but also significantly elevated cortisol, prolactin, and appetite effects mediated through the same ghrelin receptor but via pathways not directly related to GH secretion
Moreover, the maximal half-life of unassisted dissociation of a complex with pK D 13, is approx
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