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Adenylyl cyclase activation modulates activity-dependent changes in synaptic strength and Ca 2+ /calmodulin-dependent kinase II autophosphorylation
Systemic reactions may include nausea, mood changes, or hormonal shifts that impact menses or sperm parameters
One sailed through safety trials but stumbled on efficacy
Until the recent breakthrough on preparation of 15 N-labeled cobalamins via biosynthesis [8] and further development of the first multiple stable isotope dilution assay (SIDA) that simultaneously determines the four natural vitamers [7], the quantification of B12 in foods has been relying on methods mainly applying microbiological assays [9, 10], (U)HPLC-UV [11,12,13,14,15,16,17], and occasionally LC-ICP-MS [18]
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