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Nausea, diarrhea, vomiting, constipation, abdominal discomfort, and reduced appetite are among the most commonly reported adverse effects of GLP-1-based weight-loss medications

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Limited studies using hyperinsulinemic-euglycemic clamp techniquesthe gold standard for measuring insulin sensitivitysuggest that GLP-1 receptor agonists may improve peripheral insulin sensitivity, primarily through weight loss rather than direct cellular effects

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