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Oral semaglutide 50 mg taken once per day in adults with overweight or obesity (OASIS 1): a randomised, double-blind, placebo-controlled, phase 3 trial One randomized, double-blind, placebo-controlled trial evaluated the safety and effectiveness of oral semaglutide (GLP-1) 50 mg, taken once daily in adults with overweight or obesity who did not have type 2 diabetes