It should be pinpointed that while GIP acts almost exclusively at the pancreatic level, there are widely distributed receptors for GLP-1 (R-GLP1) in the endocrine pancreas ( and ), in heart, stomach, adipose tissue, vagus nerve and in various regions of the central nervous system
[19] [20] More serious but rare risks include pancreatitis (severe abdominal pain radiating to the back), gallbladder disease (right upper quadrant pain, fever, jaundice), and potential thyroid C-cell tumors (based on animal data)
[1] If flu-like symptoms are accompanied by high fever, significant respiratory symptoms, chest pain, or if you feel severely unwell in a way that seems disproportionate to typical Wegovy side effects, do not assume it is medication-related
For females, there were more hip fractures with semaglutide (0.3% vs