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In one landmark trial, adults without diabetes who took the highest weekly dose lost an average of 20.9 percent of their body weight over 72 weeks, compared with 3.1 percent on placebo, and more than half reached at least a 20 percent reduction (SURMOUNT-1 trial, New England Journal of Medicine, 2022)

10.1152/physrev.00022.2020 54 CoelhoF

After surgery, the body needs to heal damaged tissues, whether they are muscles, tendons, or ligaments

Also published in Nature Medicine , the correspondence notes that access to nutrition advice, affordable healthy food, and ongoing healthcare support is likely to influence whether patients can use these drugs safely and sustain health improvements over the long term