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Suh JH, Shenvi SV, Dixon BM, Liu H, Jaiswal AK, Liu R-M, et al
It is a dual GIP and GLP-1 receptor agonist, meaning it targets two hormonesglucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)to regulate blood sugar levels, reduce appetite, and improve fat metabolism
The analysis also identified a nonlinear dose-response relationship, with 2,000 mg per day offering the most benefit for weight reduction
Circadian regulation of L-cell activity in rats is highly sensitive to disturbances in circadian rhythms, as continuous light conditions eliminate normal changes in GLP-1 and insulin nutrient-induced responses and significantly impair glucose tolerance (19), Moghadam and his team similarly found that basal levels of GLP-1 were higher in rats under dark conditions (56), and sensitivity was highest (74)
