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The most commonly reported adverse effects include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and constipation, rather than neurological pain syndromes
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Conversely, oxidative stress exacerbates this aging process by facilitating endothelial dysfunction, vascular remodeling, cardiac hypertrophy, and inflammation ( Oxidative stress causes lipid peroxidation and ROS-mediated protein modifications, including the formation of cross-links and carbonyl groups or the breaking of polypeptide chains
Feuer DS, et al
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