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10.1155/2014/360438 17 AzambujaP.GarciaE

Recognizing these GLP-1 non-responders promptly allows clinicians to adjust treatment strategies before patients experience prolonged periods without meaningful results, potentially leading to frustration and treatment abandonment

Ghrelin and other appetite hormones rebound above baseline, making portion control and food choice discipline significantly more difficult without pharmaceutical support or exceptional behavioral reinforcement