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International Journal of Molecular Sciences, 2025 DOI: 10.3390/ijms262411774 #MultipleSclerosis #Neuroimmunology #Biomarkers #OCT #DisabilityProgression #ClinicalResearch #Neurology To view or add a comment, sign in Exploring extracellular vesicles as diagnostic tools in gutbrain axis disorders: in this concise review article, Patricia Maral da Costa, Reinaldo Barreto Ori at Federal University of Ceara and collaborators integrated microbial- and brain-derived extracellular vesicles within the framework of gutbrain axis disorders and proposed three translational diagnostic niches: microbial EVs as systemic indicators of dysbiosis and immune activation, brain-derived EVs as liquid biopsies of central nervous system pathology, and engineered or technologically captured EVs as platforms for point-of-care testing