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Summary: Retatrutide is an investigational triple receptor agonist (GLP-1, GIP, and glucagon) showing promising early weight-loss and metabolic data in Phase 2 trials, but it is not yet approved in the UK and carries notable side effects and safety uncertainties

Contact your GP if you have no bowel movement for more than seven days despite laxatives, severe abdominal pain with vomiting, rectal bleeding, unexplained weight loss, or if over-the-counter laxatives provide no relief after one week

In this sense, it is important that pharmacological treatment of T2DM provides not only glycemic control, but also cardiovascular safety and clinically sound benefits in terms of reducing cardiovascular events

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