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The problem with inexpensive glutathione supplements is that GSH is inherently unstable: the thiol group of the molecule oxidises relatively quickly to the inactive GSSG form upon exposure to heat, light or oxygen
Glutathione Reductase Uses NADPH The enzyme that converts GSSG back to GSH primarily uses NADPHnot NAD+ directlyas its reducing power
However, structured cycling with breaks is recommended to maintain receptor sensitivity
Connected by a disulfide bond (SS), which has been shown to be more stable in water and high temperatures than oxidized glutathione
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