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Thus, although some of the damage in this experimental model of colitis reflects a direct erosive effect of TNBS and ethanol, their combined administration to rats reflects the in vivo operation of the damaging mechanisms elicited by TNBS, namely GSH depletion and ROS generation, indicating that ethanol facilitates the access of TNBS to the cell interior ensuring TNBS-induced GSH depletion and ROS generation
The fancy-pants genetics people call these variations polymorphisms. A polymorphism is a slight difference in the DNA between people that may lead to differences in how a protein functions
Moreover, mice blood analysis revealed marked decreases in the population of T315I-Bcr-Abl-32D/EGFP + cells by the combination of JMF4073 with UK-5099 treatment (Fig
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