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These are unstructured bursts of movement during normal life: chasing your kid, sprinting upstairs, walking fast to catch a bus Researchers measured this with wrist accelerometers, not self-report questionnaires
ROS and oxidatively modified macromolecules function as damage-associated molecular patterns (DAMPs), engaging pattern recognition receptors (PRRs) on microglia, including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), to initiate inflammatory cascades ( Microglia, the resident immune cells of the CNS, are tightly regulated under physiological conditions to maintain neural homeostasis
This prevents confusion later when you are pulling doses at different points in the vial's life
