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BPC-157 has shown a strong safety profile in both animal and early human studies

As a co-therapy like in case of combined collagen crosslinking (CXL) and intrastromal corneal ring segment (ICRS) implantation to treat keratoconic eyes, no adverse effect from the riboflavin injections were reported (32)

MOTS-c also influences the folate cycle through AICAR accumulation [2], raising an unresolved question about interaction with methotrexate or other antifolate medications