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Semaglutide 2.4 mg (Wegovy), a once-weekly GLP-1 receptor agonist licensed by the MHRA and recommended by NICE (Technology Appraisal TA875) for use in specific circumstances, demonstrated mean weight loss of approximately 14

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People who are otherwise healthy may be less willing to accept these potentially serious adverse events. GLP-1 agonists were originally developed for managing Type 2 diabetes, but exploded in popularity over the past decade as an off-label weight-loss tool, reaching approximately 40 million prescriptions in the U.S