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A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts

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In db/db mice, dapagliflozin reshapes the gut microbiota and redirects tryptophan metabolism toward increased L-tryptophanderived metabolites, leading to augmented GLP-1 production, higher circulating GLP-1 and C-peptide levels, and expansion of -cell mass via enhanced proliferation

However, recent research has shown that retinal nerve cell dysfunction occurs before retinal vasculopathy, leading to the current understanding of DR as a neurovascular disease (3436)