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A topical numbing cream can be applied prior to the injection if you need it
Researchers investigated the safety and efficacy of an intra-articular injection of BPC 157 (body protection compound-157) for various types of knee pain (1)
A particular relationship was established with the NO-system, and the advantage of the BPC 157 over the corresponding standard agents (i.e., corticosteroids, sulfasalazine, H2 blockers, anticholinergics, and proton pump inhibitors) which showed only weak, if any, effect on these fistulas closing (Klicek et al., 2008
The proposed mechanism centers on modulation of the nitric oxide system: BPC-157 counteracts L-NAME-induced eNOS blockade in rat models and supports vascular sprouting through VEGFR2 internalization (Hsieh et al., J Mol Med , 2017)
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