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GLP-1 analogues delay gastric emptying ( When initiating GLP-1based therapy, clinicians should adhere to the principle of do no harm , particularly during the early phases of treatment when gastrointestinal adverse effects are most likely to emerge ( Potentially the easiest way to prevent nausea and vomiting is by starting at a low dose ( In most cases of Grade 1 or 2 nausea, maintaining the current dose for one to two additional dosing intervals is sufficient to allow symptom resolution

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Herein, we showed experimental evidence for the anti-inflammatory properties of minocycline using both the prophylactic and treatment approaches, and its ability to synergize with two corticosteroids, methylprednisolone and budesonide, in an established colitis setting (using the treatment approach)