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These mechanisms, while therapeutically useful, also carry the potential for serious harm

Research suggests that combining weight-management medication with regular exercise may support healthier maintenance of weight and body composition over time compared with either strategy alone

A 2022 clinical trial funded by Novo Nordisk (which makes Ozempic and Wegovy) found that a weekly dose of one GLP-1 drug reduced heavy-drinking days and total intake for people struggling with alcohol use disorder but only in a subgroup of patients with a BMI over 30

For some people, even consistent and dedicated efforts lead nowhere, making them frustrated or discouraged from going on