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H., Kohli R., Gores G

Patients who report a severe delayed immune-mediated reaction (e.g., drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome or toxic epidermal necrolysis, acute generalized exanthematous pustulosis, drug-induced nephritis or hepatitis) should subsequently avoid the culprit drug, as this can be regarded as a contraindication to future use

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Therefore, although oxidants play key roles in pathogen killing and resolution of inflammation, oxidative stress caused by cigarette smoke and macrophage activation contributes to the pathophysiology of COPD by creating a vicious circle that is difficult to stop once started (Figure 2)