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Retatrutide can also cause dysesthesia (tingling, numbness) at higher doses

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Clinical studies have used schedules more intensive than those seen in recovery practice: patients with Parkinson's disease received 1,400 mg three times a week for four weeks (Hauser et al., Movement Disorders 2009, PMID 19230029), while studies on skin lightening used 1,200 mg twice a week for six weeks (Alzahrani et al., Cureus 2025, PMID 40013212)