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Blood 2005

3.2.4 Developmental and drug-induced microbiome disruption Disruptions to the gut microbiome during early development or the initial phases of psychiatric illness may influence the trajectory of mental disorders (Lavebratt et al., 2019) reported that early-life antibiotic exposure is linked to modestly increased risks for several childhood psychiatric disorders, including mood disorders, suggesting sensitive developmental windows for microbiome perturbations (Lavebratt et al., 2019)

SHBG testing is also valuable when monitoring oral versus transdermal hormone therapy, as oral estrogens significantly raise SHBG (which can bind up testosterone, worsening libido despite treating other symptoms)