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Thus it is not surprising that compounds that increase the activity of the P450 enzymes, such as caffeine[40, 41] and anticonvulsant drugs[42] also make APAP more hepatotoxic
Known sensitivity to any component , including cobalt/B12 hypersensitivity
To counteract ROS, the body relies on enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR), alongside nonenzymatic antioxidants such as vitamins C and E and reduced glutathione (GSH) [25]
It highlighted gaps in long-term data beyond 612 months and heterogeneity in dosing protocols [5][26]
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