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Philis-Tsimikas A, Billings LK, Busch R, Portillo CM, Sahay R, Halladin N, et al
NAD+ to fuel the mitochondrial "engine" to create energy
The mechanisms described below reflect current scientific understanding, including data from the 2023 phase 2 trial published in the New England Journal of Medicine (NEJM), as well as preclinical and mechanistic research
Discontinuation and Duration Dependent Cardiovascular Risk Compared with continual use of GLP-1s, discontinuing treatment for 6 months was associated with a 4% increased risk of major adverse cardiovascular events
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