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NLY01, an engineered Ex-4, effectively blocks the A-induced activation of the microglia and prevents the conversion of the microglia into reactive astrocytes in transgenic AD mouse models (5xFAD and 3xTg-AD) [85]
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if 1% or more of body weight has not been lost, it is unlikely the patient will achieve and sustain clinically meaningful weight loss with continued treatment and this drug should be discontinued
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