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Miller NR, Arnold AC

[3] Ipamorelin appears to act through the growth hormone secretagogue receptor type 1a (GHS-R1a), commonly referred to as the ghrelin receptor, located in the hypothalamus and pituitary

In SURMOUNT-1, the most common treatment-emergent adverse events were gastrointestinal: nausea (24.6-33.3% across doses vs 9.5% placebo), diarrhea (18.7-21.2%), vomiting (5.7-12.2%), and constipation (5.8-11.5%)