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In contrast, the buildup of lipid ROS and the consequent onset of ferroptosis can be hindered through intervention with iron-chelating agents (e.g., deferoxamine) and lipophilic antioxidants (e.g., ferrostatin-1 and liproxstatin-1) [77]

Temporary tolerance is achieved in hours and can be maintained if drug antigens are administered at regular intervals, depending on the drugs pharmacokinetic parameters [10]