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Hepatic TH signaling governs the GLP-1 production and glucose homeostasis As the glucose-lowering effect has been reported for either TR-selective agonist or liver-specific TR-selective agonist in obese mice 17,18 , we then employed mice lacking TR in the liver (LTRKO mice) we developed recently (Supplementary Fig
2020) reported that, although parameters such as particle size and PEGylation influence nanoparticle cellular uptake, these characteristics exert only a limited effect on their overall translocation to the central nervous system
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A tripeptide molecule present in nearly every cell, with highest concentrations in the liver, kidneys, and lungs
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