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To fully assess the effects of semaglutide in slowing disease progression, the evoke/evoke+ trials enrolled participants with late-stage MCI (defined as a CDR global score of 0.5 along with a CDR domain score of 0.5 in at least one of the three activities of daily living categories), who may be more likely to progress to mild AD dementia during the trial
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Luckily, inactive GSSG can be regenerated back into an active GSH form, thanks to an enzyme termed glutathione reductase
As these become available, the compounding question may become less relevant for many patients
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