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had been demonstrated as cardioprotective against doxorubicin-induced toxicity, without compromising the antitumor activity of that drug (Khan et al
A randomized, double-blinded, placebo-controlled trial showed that 20 mg of melatonin for breast cancer before and during the first cycle of adjuvant chemotherapy modulated serum levels of brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin kinase B (TrkB), suggesting a neuroprotective effect of melatonin [57]
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The hyaluronic acid creates a hydrated environment that enhances peptide penetration without any conflicting pH requirements
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