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doi: 10.1186/s43556-022-00110-2 72 MaccalliniCAmmazzalorsoADe FilippisBFantacuzziMGiampietroLAmorosoR

In practice, this changes procurement and oversight in several ways: Product positioning needs to be precise because labeling should stay within laboratory, analytical, or preclinical research use Vendor claims need scrutiny because promotional language can drift into drug-like implications that do not match the products status Study records need clear intent because the material should be tied to defined research activities rather than any human-use assumption Combination products deserve extra caution because a stack can look more developed than the evidence behind each component or the blend itself A simple screening question helps: if the seller describes a KLOW-style blend like an established treatment, the compliance risk rises immediately

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December 2025: Sanofi advanced its GLP-1 portfolio with updated real-world evidence for Soliqua and Lyxumia, targeting improved cardiovascular outcomes in type 2 diabetes patients