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Inherited forms stem from autosomal recessive CYB5R3 gene variants or autosomal dominant globin gene variants, collectively known as HbM disease
doi: 10.1158/1541-7786.MCR-17-0256 49 MakinoYUenishiROkamotoKIsoeTHosonoOTanakaHet al
This should be adjusted to a BMI of 25kg/m 2 for people from black, Asian and other minority ethnic groups as evidence suggests that these groups are at a higher risk of diabetes and other health conditions than white populations at a lower BMI[16]
The third the key duration-extending modification attaches a C18 fatty diacid chain to lysine at position 26, via a mini-PEG spacer
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