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The area under the concentration curve obtained when administered at the same dose, corresponds approximately to twice that obtained when it is applied by oral or rectal route, as the active principle is metabolized almost 50% during its first passage through the liver (first pass effect), when administered by the routes mentioned
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I guess that's because usually there aren't any - even the acne only affects a very few people
Astro photographic tour in the Atacama Desert
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