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[39] Pregnancy 11% risk of birth defects and 30-40% risk of neuro-developmental disabilities which can be permanent [40] Known hypersensitivity to valproate or any of the ingredients used in the preparation [39] Urea cycle disorders [39] Hepatic porphyria [39] Hepatotoxicity [39] Mitochondrial disease [39] Pancreatitis [39] Porphyria [41] Adverse effects [edit] Most common adverse effects include: [3] Nausea (22%) Drowsiness (19%) Dizziness (12%) Vomiting (12%) Weakness (10%) Serious adverse effects include: [3] Bleeding Low blood platelets Encephalopathy Suicidal behavior and thoughts Low body temperature Valproic acid has a black box warning for hepatotoxicity, pancreatitis, and fetal abnormalities