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Abstract Purpose of Review This review provides the most recent update of metformin, a biguanide oral antihyperglycemic drug used as a first-line treatment in type 2 diabetes mellitus

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This model incorporated additional processes such as chronic inflammation, dysbiosis, and impaired macroautophagy [3]

Mice in which the MCH1R gene has been knocked out exhibit less anxiety-like behaviors than wild-type mice