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Understanding the Significance of CPT Modifiers in Medical Coding Common CPT Modifiers Anesthesia has its own modifiers that correspond to a patients health condition: P1 Normal, Healthy Patient P2 Patient with Mild Systemic Disease P3 Patient with Severe Systemic Disease P4 Patient with Severe Systemic Disease That is a Constant Threat to Life P5 Moribund patient who is not expected to survive without the operation P6 Declared brain-dead patient whose organs are being removed for donor purposes Review the proper use of each modifier