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The Rac1 activator, phorbol 12-myristate 13-acetate (PMA), significantly increased the protein expression levels of MMP-2, -3, -9, and -19, whereas rhein and the Rac1 inhibitor, NSC23766, produced opposite effects

Immune cells called macrophages can infiltrate adipose tissue and drive further inflammatory processes that contribute to insulin resistance

Intended for qualified laboratory research.

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