i accidentally took 100 units of semaglutide to much on my first dose : r/Semaglutide Semaglutide & Tirzepatide Dosing Guide:

[13] These findings are further reinforced by pharmacovigilance data from the FDA Adverse Event Reporting System (FAERS) database (n=48,214 reports), where GLP-1RA-related gastrointestinal adverse events, including nausea (9651 vs 38,030) and vomiting (4383 vs 17,062), were lower with combination therapy compared to GLP-1RA monotherapy, suggesting improved tolerability when metformin is added

& Roberts, E

However, although berberines impact on weight loss is less effective than new therapies, there is some evidence to suggest that it can have other health benefits

The most frequently reported adverse effects involve gastrointestinal symptoms, which typically emerge during the initial days to weeks of supplementation as the gut microbiome adjusts to the introduced bacterial strains