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Amgens long-acting monthly obesity therapy MariTide (maridebart cafraglutide, formerly AMG 133) demonstrated substantial and sustained weight loss in a Phase II trial, with patients achieving an average of 20% weight loss without a plateau, along with cardiometabolic improvements, over 52 weeks

The ADA highlights the benefits of combining GLP-1 receptor agonists with SGLT2 inhibitors, stating: Combined use [of GLP-1 RAs and SGLT2 inhibitors] may be considered for additive cardio-kidney protection

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Some plans require a 6-month documented history of diet and exercise before approving GLP-1 coverage