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Lu Y, Li L, Lin Z et al

During this phase toxins like heavy metals, environmental chemicals, pesticides, and alcohol byproducts, bind to glutathione and become water-soluble so your body can eliminate them through urine or bile

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The appetite effect is a matter of neural signaling: area postrema neurons project to the parabrachial nucleus and onward to forebrain regions that govern the decision to stop eating, and this circuit also engages hedonic pathways that reduce the rewarding value of food