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Those effects were described to be mediated via different mechanisms including downregulation of the receptor for AGE (RAGE) (112), activation of cAMP/PKA signaling and IL-6 production (113), reduction of ROS generation and ICAM-1 expression (114), and diminishing DPP-4-activated phosphatidylinositol 3-kinase signaling which favors adipocyte maturation (115)

Personalized Medicine: Future research should explore the potential for personalized medicinal approaches using -blockers based on individual patient characteristics, such as genetic factors, metabolic profiles and comorbidities

Results differ from person to person