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Researchers (Doctors and Nurses : Angioni A, Armentano V, Ballauri C, Botta A, Bova A, Calzolari G, Canu L, Capuano G, Caraffa F, Cavani R, Cavuto L, Cimitan F, Ciotola M, Clemente G, Colarusso S, Corsini R, Cristofanelli L, Cucco L, Del Buono A, De Rosa N, Di Blasi V, Di Levrano G, Di Loreto C, Felace G, Fiorentino R, Focardi M, Gaeta I, Gaiofatto R, Garrapa G, Gentile L, Guarino G, Guida D, Lai M, Lalli C, Landini C, Lucia E, Maino S, Manfrini S, Marcone ATM, Marino C, Marino G, Mazzocchi L, Merlini A, Miranda C, Moscatelli C, Musto B, Oliva D, Oliviero B, Pasquero A, Piastrella L, Pisanu P, Pollace M, Raffaele A, Ravera M, Russo E, Scarpitta A, Speese K, Strollo F, Sudano M, Tommasi E, Tonutti L, Turco S, Uberti M, Viberti P, Vinci C, Zambroni M, Zamparo F, Zenoni L, Zoffoli M

Weight loss also typically increases sex hormone-binding globulin (SHBG) levels as insulin sensitivity improves, which affects the interpretation of total versus free testosterone measurements

European Journal of Endocrinology, [online] 191(1), pp.R22R31

In addition, intranasal administration offers the potential advantages of a more rapid onset of action and avoidance of first-pass metabolism [28]