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This finding is of direct physiological relevance, as all other active metabolites in the used fecal supernatants were still present but mere inhibition of zonulin was sufficient to restore the impaired intestinal barrier function

Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice

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GSSSG (FW: 644.70), which has also exhibited a potent preventive effect on HGF nitration (Figure 1b), did not show an enhancement of c-met binding with HGF, as described earlier (Figure 1e bars 47 ), directly encouraging the notion that there is a nitration-independent mechanism centered on the unique characteristics of LASSS on HGF