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The infection becomes sepsis when that response becomes excessive, harmful, disbalanced and leads to systemic inflammation, probably due to immunosuppression (5)

Factors conferring relative protection to children from the toxic effect of paracetamol overdose include increases in paracetamol sulphation capacity [44,45,46,47,48], relative immaturity of the CYP450 oxidation system [15, 46, 49, 51] and the larger relative liver volume found in children [59] but these theoretical mechanisms have not been confirmed