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Furthermore, the apoptosis-inducing effect and mechanism of FOXO4-DRI in a serum limitation-induced senescent fibroblast and organ culture models of keloids were examined
and reduction of neutrophil recruitment, adhesion, and migration
It also responds to oxidative stress and hypoxic conditions, common in solid tumors, through mechanisms involving ROS and hypoxia-inducible factors (HIFs) (Figure 1)
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